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Light chain-bridged bispecific antibody
专利权人:
DCB-USA LLC;Development Center for Biotechnology
发明人:
Hsu, Yu-shen,Sheu, Show-shan,Chang, Ming-I,Lo, Cheng-kai
申请号:
AU2012362378
公开号:
AU2012362378B2
申请日:
2012.12.27
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
This invention describes a novel format of monomeric bispecific fusion protein with immune activating property for clinical therapies. A bispecific fusion protein includes a first targeting domain with a specificity for a first target of interest; a bridging domain derived from a constant region of a light chain or heavy chain of an immunoglobulin, which may be a human immunoglobulin; and a second targeting domain with a specificity for a second target of interest. The bispecific fusion protein may further include a linker fused to the N-terminus or the C-terminus of the bridging domain. The first targeting domain is fused to the bridging domain and the second targeting domain is fused to the bridging domain or the linker. The linker may include a GGGGS sequence. The first target of interest may be CD20, Her2/neu, or EpCAM, and the second targeting domain is a T-lymphocyte activating domain.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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