Disclosed is a binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises a first VD1-(X1)n-VD2-C-(X2)n, wherein: VD1 is a first heavy chain variable domain； VD2 is a second heavy chain variable domain； C is a heavy chain constant domain； X1 is a linker with the proviso that it is not CH1； X2 is an Fc region； n is independently 0 or 1； and wherein said second polypeptide chain comprises a second VD1-(X1)n-VD2-C-(X2)n, wherein: VD1 is a first light chain variable domain； VD2 is a second light chain variable domain； C is a light chain constant domain； X1 is a linker with the proviso that it is not CH1； X2 does not comprise an Fc region； n is independently 0 or 1； and wherein, in said first polypeptide chain, VD1 comprises the amino acid sequence of SEQ ID NO: 204； and VD2 comprises the amino acid sequence of SEQ ID NO: 213； wherein, in said second polypeptide chain, VD1 comprises the amino acid sequence of SEQ ID NO: 238； and VD2 comprises the amino acid sequence of SEQ ID NO: 216； and wherein the binding protein binds human IL-1&bgr； and human IL-1&alpha；. Further disclosed is a binding protein wherein the VD1 and VD2 of the first and second polypeptides as described above are reversed.
