Roger Craig;Erasmus University Medical Center Rotterdam
发明人:
Craig, Roger Kingdon,Grosveld, Franklin Gerardus,Janssens, Richard Wilhelm,Drabek, Dubravka
申请号：
AU2010212518
公开号：
AU2010212518B2
申请日:
2010.08.24
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2010212518B220130314.pdf#####ABSTRACT The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The 5 invention also relates to the manufacture and use of a diverse repertoire of classspecific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. The present invention also relates to a method of 10 generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.
