Erasmus University Medical Center Rotterdam;Craig, Roger Kingdon
发明人:
申请号：
EP10179784.3
公开号：
EP2311874B1
申请日:
2005.07.22
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention relates to a binding polypeptide complex comprising a dimer of a first heavy chain and a second heavy chain wherein: each heavy chain comprises a binding domain, an effector moiety and a dimerisation domain； the binding domain in the first heavy chain is either of the same specificity as, or of a different specificity from, the specificity of the binding domain in the second heavy chain； the effector moiety in the first heavy chain has the same or different function from the effector moiety on the second heavy chain； and each dimerisation domain comprises at least C H 2, C H 3 and optionally C H 4 antibody constant domains derived from the any class of immunoglobulin heavy chain gene.
