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Di- and triphosphate prodrugs
专利权人:
Universitaet Hamburg
发明人:
Meier Chris,Gollnest Tristan,Nack Tobias,Weinschenk Lina
申请号:
US201515505281
公开号:
US10131685(B2)
申请日:
2015.08.17
申请国别(地区):
美国
年份:
2018
代理人:
Pendorf Stephan A.`Patent Central LLC
摘要:
Compounds which can be used as prodrugs, in particular nucleoside diphosphate and triphosphate prodrugs, and a method for producing these compounds. The aim is to provide improved di- and/or triphosphate prodrugs, in particular nucleotide or nucleotide analog prodrugs. This is achieved in one aspect by providing bioreversibly and asymmetrically masked di- and triphosphate compounds, in particular nucleoside diphosphate and nucleoside triphosphate compounds or the analogs thereof. The masking only occurs at the terminal phosphate, i.e. at the β- or γ-phosphate, whereas the masking of the internal phosphate is omitted.
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