The Trustees of the University of Pennsylvania;The Wistar Institute of Anatomy and Biology
发明人:
Carl H. June,Ellen Pure,Liang-Chuan Wang,Steven Albelda,John Scholler
申请号：
US14042306
公开号：
US09365641B2
申请日:
2013.09.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.
