THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
发明人:
JUNE, CARL, H.,PURE, ELLEN,WANG, LIANG-CHUAN,ALBELDA, STEVEN,SCHOLLER, JOHN
申请号：
EP13843099
公开号：
EP2904106A4
申请日:
2013.09.30
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.
