Incorporation in vivo d'acides aminés d'alkynyle dans des protéines d'eubactéries

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专利权人:

The Scripps Research Institute

发明人:

申请号：

EP14167563.7

公开号：

EP2770053A1

申请日:

2005.09.20

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a cubacteria host such ass E. coli. The invention provides novel orthoghonal synthetases methods for identifying and making the novel synthetases methods for producing proteins containing alkynyl amino acids, and cellular translation systems.

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