PARK, Suck Yong,박석용,JI, Hyun Ku,지현구,CHOI, Ju Hwan,최주환,CHOI, Sung Up,최성업,CHO, Seong Wan,조성완,KIM, In Su,김인수,HWANG, Sung-Joo,황성주
申请号：
KRKR2016/008842
公开号：
WO2018/030559A1
申请日:
2016.08.11
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present invention relates to a combined preparation containing telmisartan, capable of being prepared into a single-layer tablet and, more specifically, to an antihypertensive combined preparation containing, as active ingredients: telmisartan and amlodipine as a calcium channel blocker or other antihypertensive drugs of hydrochlorothiazide as a diuretic, wherein telmisartan forms a granule with a binder, a disintegrating agent, a lubricant, and an excipient, which comprises an aluminum magnesium silicate compound and anhydrous dibasic calcium phosphate, telmisartan is contained in a weight ratio, in which telmisartan : the aluminum magnesium silicate compound = 1 : 0.2-0.5, and telmisartan and the other antihypertensive drugs are contained together in the same layer. The telmisartan combined preparation of the present invention: even if prepared into a single-layer tablet, has no difficulty in the elution of each ingredient particularly, guarantees safety and efficacy by exhibiting elution equivalence and bioequivalence of telmisartan and Twynsta tabletTM or Micardis plus tabletTM, which is an original medicine guaranteeing safety and efficacy is also very stable by not generating impurities has an advantage of allowing various packing methods such as a PE bottle and a PTP package in the packing of a tablet by being highly stable in the presence of moisture and, further, has effects of reducing preparation costs and time by being simply preparable into a single layer through a direct compression method.La présente invention concerne une préparation combinée contenant du telmisartan, pouvant être préparée en un comprimé monocouche et, plus spécifiquement, une préparation combinée dantihypertenseur contenant, en tant que principes actifs : du telmisartan et de lamlodipine en tant que bloqueur des canaux calciques ou dautres médicaments antihypertenseurs dhydrochlorothiazide en tant que diurétique, où le telmisartan forme un granule avec un agent liant, un agent
