Various multi-lumen caps and methods of use are provided herein that can be integrated with devices configured to image target tissue from a body cavity. In an exemplary embodiment, an imaging sleeve is provided with an elongate shaft having distal and proximal ends. The elongate shaft is configured to receive at least a portion of an imaging device therein, and an engagement member is disposed on the proximal end and configured to engage with the imaging device. A cap is configured to removably attach to the distal end of the elongate shaft and engage each of the plurality of lumens. The cap is configured to seal one or more of the plurality of lumens and to leave open one or more of the plurality of lumens.
