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ANTIBACTERIAL BIAROMATIC DERIVATIVES
专利权人:
ACTELION PHARMACEUTICALS LTD
发明人:
CREN, SYLVAINE,FRIEDLI, ASTRID,HUBSCHWERLEN, CHRISTIAN,RUEEDI, GEORG,ZUMBRUNN, CORNELIA
申请号:
PH12015502411
公开号:
PH12015502411A1
申请日:
2015.10.16
申请国别(地区):
PH
年份:
2016
代理人:
摘要:
The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (l-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-l-yl or 3,4-dihydroxycyclopentyl)methoxy U1 is N or CR1, U2 is N or CR2, U3 is N or CR3 and U4 is N or CR4, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time R1 is H, cyano, hydroxy or alkoxy R2 is H, hydroxy or alkoxy R3 is H, cyano, hydroxy, alkoxy or carboxamido R4 is H or alkoxy R5 is H, hydroxy or halogen R6 is H, hydroxy or halogen R7 is H the dotted line "_____ " represents a bond or is absent W represents CH or N when the dotted line "_____ " is a bond, or W represents CH2 when the dotted line "_____ " is absent X represents CH or N and Q represents O or S and salts thereof.
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