ASTRID FRIEDLI,CHRISTIAN HUBSCHWERLEN,CORNELIA ZUMBRUNN,GEORG RUEEDI,SYLVAINE CREN
申请号：
BR112015026261
公开号：
BR112015026261A2
申请日:
2014.04.15
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (1-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-1-yl or 3,4-dihydroxycyclopentyl)methoxy； U1 is N or CR1, U2 is N or CR1, U3 is N or CR3 and U4 is N or CR1, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time； V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time； R1 is H, cyano, hydroxy or alkoxy； R2 is H, hydroxy or alkoxy； R3 is H, cyano, hydroxy, alkoxy or carboxamido； R4 is H or alkoxy； R5 is H, hydroxy or halogen； R6 is H, hydroxy or halogen； R7 is H； the dotted line &ldquo；______&rdquo； represents a bond or is absent； W represents CH or N when the dotted line &ldquo；______&rdquo； is a bond, or W represents CH2 when the dotted line &ldquo；______&rdquo； is absent； X represents CH or N； and Q represents O or S； and salts thereof.
