The present invention provides a method for determining a salient reactivity of at least one target sensory stimulus applied to a subject, the method comprising:- obtaining physiological signals from the subject during a stimulation with the target sensory stimulus and during a stimulation with a reference sensory stimulus, the physiological signals comprising a plurality of channels,- determining, at a plurality of time points of the physiological signals, topographic spectral power maps, wherein a topographic spectral power map comprises spectral powers of frequency bands of the plurality of channels,- clustering the topographic spectral power maps to obtain a plurality of macrostates,- identifying, among the plurality of macrostates, a default macrostate as the macrostate which shows a largest suppression during stimulation, and- determining the salient reactivity based on a difference between the suppression of the default macrostate during the target sensory stimulus and a suppression of the default macrostate during the reference sensory stimulus.
