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ANTISENSE OLIGONUCLEOTIDE MODULATION OF RAF GENE EXPRESSION
专利权人:
Brett P. Monia
发明人:
Brett P. Monia
申请号:
US13185406
公开号:
US20120149755A1
申请日:
2011.07.18
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Oligonucleotides are provided which are targeted to nucleic acids encoding human raf and capable of inhibiting raf expression. The oligonucleotides may have chemical modifications at one or more positions and may be chimeric oligonucleotides. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating or preventing conditions, including hyperproliferative conditions, associated with raf expression.
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