Karlheinz Baumann,Guido Galley,Roland Jakob-Roetne,Anja Limberg,Werner Neidhart,Rosa Maria Rodriguez Sarmiento,Björn Bartels,Hasane Ratni
申请号：
US15913087
公开号：
US20180237432A1
申请日:
2018.03.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formulahetaryl is a five membered heteroaryl group, containing 1 to 3 heteroatoms, selected from O, S or N；R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, S-lower alkyl substituted by halogen or lower alkoxy substituted by halogen, or two neighboring carbon atoms may form on phenyl an additional ring containing —O—CH2—O—；n is 1 to 5；R2 is hydrogen or lower alkyl substituted by halogen；R3 is hydrogen or lower alkyl substituted by halogen；or to pharmaceutically active acid addition salts thereof, to racemic mixtures or to its corresponding enantiomers or optical isomers or stereoisomers thereof.The compounds may be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
