The present invention relates to a rhinovaccination system for preventing and treating hepatitis B, comprising a hepatitis B vaccine composition for administration to nasal mucosa in combination with a medical nozzle device.本發明是關於一種用於B型肝炎的預防及治療的經鼻投予系統,其係將經鼻黏膜噴霧投予用B型肝炎疫苗組成物,與用於鼻腔黏膜投予的醫療用噴嘴器具組合而成者。