Tokyo Metropolitan Institute of Medical Science;National Univers;Toko Yakuhin Kogyo Co., Ltd.;Japan as represented by Director General of National Institute of Infectious Diseases;Kagoshima University
The present invention relates to a hepatitis B vaccine composition for nasal mucosa spraying administration, characterized by comprising a hepatitis B antigen and a gel base containing a carboxyl vinyl polymer, and by being applicable to hepatitis B prevention and treatment.