NANOBIO CORPORATION;THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人:
Paul Makidon,Vira Bitko,Douglas Smith,Ali Fattom
申请号：
US15560057
公开号：
US20180071380A1
申请日:
2016.03.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present application relates to immunogenic compositions comprising a mixture of Bordetella (e.g., B. pertussis) antigens and an oil in water nanoemulsion. In particular, the invention provides immunogenic compositions comprising nanoemulsion and a combination of Bordetella (e.g., B. pertussis) antigens that have different functions, for example, combinations including B. pertussis adherence factors (adhesins), B. pertussis toxins or B. pertussis virulence factors. Vaccines, methods of treatment, uses of and processes to make a pertussis or whooping cough vaccine are also described. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
