A method of treating a patient in need of treatment, to a statistically significant or no elevation of mean arterial pressure and to treat conditions of at least one of the patients pain, inflammation, and are selected from the heating It comprises in an amount effective to provide the effect that clinically relevant to the mean arterial pressure of the patient during the dosing interval including no increase and administered to critically ill patients an intravenous pharmaceutical composition comprising ibuprofen , the above method. [Selection Figure 7治療を必要とする患者を治療する方法であって、疼痛、炎症、および発熱から選択される該患者における少なくとも1種の状態を治療し、かつ平均動脈圧の上昇なしまたは統計学的に有意な上昇なしを含む投与間隔の間の該患者の平均動脈圧に対する臨床的意義がある影響をもたらすのに有効な量で、イブプロフェンを含む静脈内投与用医薬組成物を重症患者に投与することを含む、上記方法。【選択図】図7
