GIOVANNI CAVALLO,EDOARDO STAGNI,PIERRE ROY,FULVIO FOSCHINI,GIULIO LUCIANI
申请号：
MX2013004511
公开号：
MX347934B
申请日:
2011.01.12
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
An ocular iontophoresis device for delivering any ionized drug solution, such as riboflavin solution, to the cornea comprises, in combination: a reservoir (8) containing a riboflavin solution which is suitable to be merely positioned on the eye an active electrode (2) disposed in or on the reservoir (8) and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body, preferably in close vicinity of the eye, such as forehead, cheeks or neck means (10) for irradiating the cornea surface with suitable light, such as UV light, for obtaining corneal cross- linking after the delivering of drug or of Riboflavin wherein said reservoir (8) and said active electrode (2) are transparent to UV light and/or visible light and/or IR light. Method for delivering any ionized drug solution, such as riboflavin solution, to the cornea for treatment of keratoconus or any other ectasic corneal disease, or for reinforcing corneal stromal structure by means of an ocular iontophoresis device according to preceding claims, providing the following steps : - positioning said iontophoretic device on the eye to be treated, the device comprising a reservoir containing the riboflavin solution - driving the solution movement by a cathodic current applied for 0,5 to 5 min, at an intensity not higher than 2 mA - irradiation, immediately after the end of the current application, of the cornea surface with an UV light for 5 to 30 min at a power of 3 to 30 mW/cm2 thereby obtaining the corneal cross-linking of the riboflavin.Un dispositivo de iontoforesis ocular para suministrar a la córnea cualquier solución de fármaco ionizada, tal como una solución de riboflavina, comprende en combinación: un depósito (8) que contiene una solución de riboflavina, que es adecuado para ser colocado simplemente sobre el ojo un electrodo activo (2) dispuesto en o sobre el depósito (8) y un electrodo pasivo, adecuado para ser colocado sobre la piel del sujeto, en cualquier parte del cuerpo,
