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5-lipoxygenase-activating protein inhibitor
专利权人:
Kevin Murray Schaab;Nicholas Simon Stock
发明人:
Kevin Murray Schaab,Nicholas Simon Stock
申请号:
US12471106
公开号:
US08772495B2
申请日:
2009.05.22
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Described herein is the FLAP inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of preparing the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, including solvates, and polymorphs thereof. Also described herein are pharmaceutical compositions suitable for administration to a mammal that include the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, and methods of using such pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.
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