M. G. Finn,Jennifer Marie Beveridge,Allison Frances Geoghan,Zhishuai Geng
申请号：
US15610354
公开号：
US10513567B2
申请日:
2017.05.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed are polycationic polymers. The polycationic polymers can include a plurality of positively charged centers, each of which is formed by condensation of cyclic bis-electrophile (e.g., a 9-thia/aza/selenabicyclo[3.3.1]nonyl electrophile) with a nucleophile. The resulting polycationic polymers can efficiently bind nucleic acids. The polycations can also exhibit properties of cytotoxicity and DNA transfection with interesting structure-activity characteristics.
