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INNATE IMMUNE SUPPRESSION ENABLES REPEATED DELIVERY OF LONG RNA MOLECULES
专利权人:
发明人:
申请号:
EP17153389.6
公开号:
EP3248618A1
申请日:
2009.04.22
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Disclosed are methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid. Further disclosed are methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA ("ivT-RNA) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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