MAURICE JOSEPH PRENDERGAST,ROSS STRAND,XIAOLI WANG
申请号：
BRPI0820299
公开号：
BRPI0820299B1
申请日:
2008.11.04
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention relates to an aqueous oral composition comprising: a) from 0.2% to 3% divalent metal ions comprising: i. from 0.1% to 1.5% of zinc ions； ii. from 0.1% to 2% oftin (II) ions； and b) a source of fluoride ions； c) a silica dental abrasive； d) one or more chelants having a MW of less than 1000 and capable of forming water-soluble complexes with the zinc ions, wherein the chelants comprise less than 0.2% linear polyphosphates having a chain length of four or more； e) an orally acceptable carrier comprising at least 20% total water； wherein the pH of the composition is from 5 to 6.5, the molar ratio of the chelants to the divalent metal ions is at least 0.70:1 and at least 80% by weight of the total zinc ions are solubilised within the composition. The composition of the invention has been found to give improved antimicrobial activity from the zinc / stannous combination without significant taste, staining or stability problems, compared to compositions having lower levels of chelants.
