The purpose of the present invention is to provide a pre-filled syringe whereby a used pre-filled syringe can reliably be distinguished even when a plunger has been slid only a short distance. A pre-filled syringe (1) has: a see-through injection tube (4) having an open part at a tube proximal end and a drug solution discharge part (41) at a tube distal end a plunger (5) inserted from the open part and having a plunger rod (53) to which a pushing part (55) is provided at a proximal end part thereof, a gasket (51) being connected to a distal end part of the plunger rod (53) and a pushing part (55) being provided to a proximal end part of the plunger rod (53) and a drug solution (42) stored in the injection tube (4) and discharged from the drug solution discharge part (41) by sliding of the plunger rod (53) and the gasket (51) due to pushing from the pushing part (55) and has: an indicator (52) affixed to the plunger rod (53), for indicating by a color and/or a design whether the drug solution has been discharged a shield part (34) for shielding the indicator (52) inside the injection tube (4) so that the indicator (52) cannot be seen and a visible part (30) for exposing the indicator (52) from the shield part (34) so that the indicator is visible in response to discharge of the drug solution (42) by sliding of the gasket (51).La présente invention vise à fournir une seringue pré-remplie permettant de différencier de manière fiable une seringue pré-remplie usagée même lorsque le piston na coulissé que sur une courte distance. La présente invention concerne par conséquent une seringue pré-remplie (1) qui a : un tube dinjection transparent (4) ayant une partie ouverte au niveau de lextrémité proximale et une partie de décharge de solution médicamenteuse (41) au niveau dune extrémité distale de tube un piston (5) inséré par la partie ouverte et ayant une tige de piston (53) ayant une partie poussoir (55) au niveau dune partie dextrémité proximale de celle-ci, une garnit
