The present disclosure provides a glass composition that include from about 50 mol% to about 95 mol% of B2O3； from about 5 mol% to about 50 mol% of one or more glass components selected from the group consisting of: Li2O, Rb2O, K2O, Na2O, SrO, CaO, MgO, and ZnO. The glass composition includes less than 30 mol% of Rb2O. The glass composition is a quaternary system. The glass composition is a particulate material that includes particles that are from about 1 to about 50 µm in size. The glass composition loses at least 5 mass% within 24 hours when exposed to a buffered saline solution. The glass composition may be used to desensitize dentin. The present disclosure also provides a dentin-desensitizing composition.本發明提供一種玻璃組合物，其包括約50莫耳%至約95莫耳%之B2O3；約5莫耳%至約50莫耳%之一或多種選自由以下組成之群的玻璃組分：Li2O、Rb2O、K2O、Na2O、SrO、CaO、MgO及ZnO。該玻璃組合物包括小於30莫耳%之Rb2O。該玻璃組合物為四元系統。該玻璃組合物為包括尺寸約1 µm至約50 µm之粒子的粒狀材料。當暴露於緩衝鹽水溶液時，該玻璃組合物在24小時內損失至少5質量%。該玻璃組合物可用於使牙本質脫敏。本發明亦提供一種牙本質脫敏組合物。
