A bioactive borate glass composition including, for example: 30 to 60% B2O3; 0.5 to 20% ZrO2; 3 to 30% Na2O; 0.1 to 15% K2O; 0.1 to 15% MgO; 5 to 30% CaO; and 1 to 5% P2O5in mole percents based on 100 mol% of the total composition. Also disclosed is a method of making and method of using the compositions and the bioactive borate glass dentin treatment formulations.一種生物活性硼酸玻璃組成物,以100莫耳%的該總組成物計,該組成物包含例如:30莫耳%至60莫耳%的B2O3;0.5莫耳%至20莫耳%的ZrO2;3莫耳%至30莫耳%的Na2O;0.1莫耳%至15莫耳%的K2O;0.1莫耳%至15莫耳%的MgO;5莫耳%至30莫耳%的CaO;及1莫耳%至5莫耳%的P2O5。亦揭示製造該等組成物的方法及使用該等組成物的方法以及生物活性硼酸玻璃牙本質治療製劑。