Mark T. Bilodeau,Sudhakar Kadiyala,Rajesh R. Shinde,Brian H. White,Richard Wooster,Benoît Moreau
申请号：
US15695214
公开号：
US20180021454A1
申请日:
2017.09.05
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Particles, including nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via a linker have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
