A needle protection device (10) for protecting a needle has a needle carrier (12) for carrying said needle (14) and being translatable along a longitudinal axis X between a first, deployed, position (D) and a second, protected, position (P)； a shuttle (16) surrounding said needle (14)； a hub (24) for receiving the needle carrier (12)； a sleeve (26) being rotatable around each of said needle carrier (12), said shuttle (16) and said hub (24)； a first driving mechanism (30) between said needle carrier (12) and said shuttle (16) to cause axial displacement of said shuttle (16) in a first direction (A) between a first, retracted position R and a second, deployed position Ds upon axial displacement of the needle carrier (12) along axis X； and a second driving mechanism (32) between said needle carrier (12) and said sleeve (26) to cause axial displacement of the carrier (12) in said first direction (A) upon rotational displacement of the sleeve (26).
