PAUL JOSEPH COX,TAHIR NADEEM MAJID,ANDREW DAVID MORLEY,SHELLEY AMENDOLA,STEPHANIE DEPRETS,CHRIS EDLIN,JUSTINE YEUN QUAI LAI
申请号：
PT08162392
公开号：
PT1990343E
申请日:
2000.12.27
申请国别(地区):
PT
年份:
2012
代理人:
摘要：
The invention is directed to compositions containing physiologically active compounds of general formula (I) wherein R<1> is aryl or heteroaryl R<2> represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z<1>R<8>,-C(=O)-NY<3>Y<4>,-CO2R<8>,-NY<3>Y<4>,-N(R<6>)-C(=O)-R<7>, -N(R<6>)-C(=O)-NY<3>Y<4>,-N(R<6>)-C(=O)-OR<7>, -N(R<6>)-SO2-R<7>,-N(R<6>)-SO2-NY<3>Y<4> and one or more halogen atoms R<3> represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, -C(=O)-OR<5> or -C(=O)-NY<3>Y and X<1> represents N, CH, C-halo, C-CN, C-R<7>, C-NY<3>Y<4>, C-OH, C-Z<2>R<7>, C-C(=O)-OR<5>, C-C(=O)-NY<3>Y<4>, C-N(R<8>)-C(=O)-R<7>, C-SO2-NY<3>Y<4>, C-N(R<8>)-SO2-R<7>, C-alkenyl, C-alkynyl or C-NO2 and their produgs, and pharmaceutically acceptable salts and solvates of such compounds and their produgs, as well as to novel compounds within the scope of fomula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.
