LARCH CHRISTOPHER PAUL,LARCH Christopher Paul,STOREY JOHN MERVYN DAVID,STOREY John Mervyn David,WILLIAMSON CRAIG,WILLIAMSON Craig,MARSHALL COLIN,MARSHALL Colin,KEMP STEVEN JOHN,KEMP Steven John
申请号：
SI201030572
公开号：
SI2430007T1
申请日:
2010.05.11
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as &ldquodiaminophenothiazinium compounds&rdquo) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF) an oxidative coupling (OC) and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimers disease (AD).
