Christopher Paul Larch;John Mervyn David Storey;Craig Williamson;Colin Marshall;Steven John Kemp
发明人:
Christopher Paul Larch,John Mervyn David Storey,Craig Williamson,Colin Marshall,Steven John Kemp
申请号：
US13318907
公开号：
US08691979B2
申请日:
2010.05.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF)； an oxidative coupling (OC)； and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).
