Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof

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专利权人:

Fajun Nan

发明人:

Fajun Nan,Jian Ding,Jianping Zuo,Linqian Yu,Linghua Meng,Yangming Zhang,Na Yang,Min Gu

申请号：

US13119700

公开号：

US08455510B2

申请日:

2009.09.17

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Rapalogs of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and preparation methods and uses thereof. The rapalogs have the structure of formula I and can be used as an anti-tumor medicament. Comparing with rapamycin, the rapalogs of the present invention exhibit enhanced water solubility, and improved pharmacological and pharmacokinetic properties by introducing a hydrophilic and polar group such as a hydroxyl.

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中国工程科技知识中心

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http://www.ckcest.cn/home/