Общество с ограниченной ответственностью "СИНТЕГАЛ" (RU)
发明人:
Худолей Владимир Николаевич (RU),Дорошенко Александр Сергеевич (RU),Постников Павел Сергеевич (RU),Трусова Марина Евгеньевна (RU),Иванов Алексей Алексеевич (RU)
申请号：
RU2013130687/15
公开号：
RU2013130687A
申请日:
2013.07.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A process for immobilization of drugs to the surface of detonation nanodiamonds based on obtaining a suspension detonation nanodiamonds and dissolving the drug in an organic or aqueous organic solvent, then evaporating the resulting slurry of the drug with nanodiamonds and drying, characterized in that the chemisorption is carried pharmaceutical preparations containing groups -NH, -NH, -COOH, -COONa, -CONH, -OH C = O on the oxidized surface nanoalmazov.2 detonation. A method according to claim 1, characterized in that the suspension detonation nanodiamonds with the drug is kept in an organic or aqueous organic solvent is not less than 24 hours under vigorous peremeshivanii.3. A method according to claim 1, characterized in that the suspension detonation nanodiamonds medicine is evaporated in an organic or aqueous-organic solvent on a rotary evaporator at a temperature not exceeding 70 ° C and a pressure in the range of 170-400 mbar.4. A method according to claim 1, characterized in that the suspension detonation nanodiamonds medicine in an organic or aqueous-organic solvent after evaporation was dried for at least 24 hours in air at room temperature.5. A method according to claim 1, characterized in that the surface of detonation nanodiamonds with chemisorbed drug solubilizing pokrytiya.6 applied. A method according to claim 5, characterized in that the coatings are used as solubilizing polyethylene glycols, polyethylene glycols or phosphorylated or fosfolipidy.7. A method according to claim 5, characterized in that the coating is applied by suspending solubilizing with1. Способ иммобилизации лекарственных препаратов на поверхность детонационных наноалмазов, основанный на получении суспензии детонационных наноалмазов и лекарственного средства растворением в органическом или водно-органическом растворителе, последующем упаривании полученной суспензии лекарственного препарата с наноалмазами и сушке, отличающийся тем, что осуществляют хемосорбцию лекарственных препа
