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PRODUCTION AND PURIFICATION METHODS FOR EFINACONAZOLE
专利权人:
LTD.;KAKEN PHARMACEUTICAL CO.
发明人:
Masahito WATANABE,Takeshi KANAYAMA
申请号:
US16795275
公开号:
US20200181110A1
申请日:
2020.02.19
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides efinaconazole producing and purifying methods adapted to industrial scale that provide high-purity efinaconazole in high yield by simple operations using specific impurities as indices. The efinaconazole producing method comprises:step A of forming a toluene solution comprising compound (II), compound (III), an inorganic base, and toluene in a volume (L) which is 2 to 5 times the mass (kg) of compound (II);step B of subjecting the toluene solution to reaction under heating;step C of washing the reaction mixture from step B to obtain a toluene solution of crude efinaconazole in which the residual amount of 4-MP is not more than 5 wt % of efinaconazole.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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