MIGAWA, Michael, T.,YU, Jinghua,WAN, W., Brad,PATEL, Satyen, P.,VASQUEZ, Guillermo,KINBERGER, Garth, A.,PRAKASH, Thazha, P.,SETH, Punit, P.,SWAYZE, Eric, E.
申请号：
EP15785492
公开号：
EP3137115A4
申请日:
2015.05.01
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods dont include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.
