An endoscopic clip applier is adapted to retain a plurality of asymmetric ligating clips in a clip channel contained within a shaft assembly (20), and includes a jaw assembly (90) for applying an asymmetric clip. The jaw assembly is connected to the distal end of the clip channel, and a handle assembly is connected to a proximal end of the clip channel. A feeder bar is mounted adjacent the clip channel, and is moveable between a proximal position and a distal position to advance clips in the clip applier and to feed a clip from the clip channel to the jaw assembly. Additionally, the shaft assembly is moveable between a proximal position and a distal position, and includes cam surfaces for closing the jaw assembly when the shaft assembly is moved in a distal direction. A trigger (144) on the handle assembly actuates the feeder bar to advance clips in the clip channel and advances the shaft assembly to close the jaw assembly. An endoscopic clip applier with ligating clips built into a clip channel. The device contains a jaw assembly with four jaw pieces. A feeder bar is mounted adjacent the clip channel. A shaft is moveable and contains cam surface for closing the jaw assembly when the shaft assembly is moved in a distal direction. A trigger on the handle assembly actuates the feeder bar to advance clips in the clip channel and advances the shaft assembly to close the jaw assembly.
