An endoscopic clip applier is adapted to retain a plurality of asymmetric ligating clips in a clip channel contained within a shaft assembly, and includes a jaw assembly for applying an asymmetric clip. The jaw assembly is connected to the distal end of the clip channel, and a handle assembly is connected to a proximal end of the clip channel. A feeder bar is mounted adjacent the clip channel, and is moveable between a proximal position and a distal position to advance clips in the clip applier and to feed a clip from the clip channel to the jaw assembly. Additionally, the shaft assembly is moveable between a proximal position and a distal position, and includes cam surfaces for closing the jaw assembly when the shaft assembly is moved in a distal direction. A trigger on the handle assembly actuates the feeder bar to advance clips in the clip channel and advances the shaft assembly to close the jaw assembly.
