Bevacizumab and 2,2-dimethyl-N-((S) -6-oxo-6,7-dihydro-5H-dibenzo [b, d] azepin-7-yl) -N ′ for the treatment of proliferative diseases -(2,2,3,3,3-pentafluoro-propyl) -malonamide
The present invention relates to a combination therapy of 2,2-dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N&prime；-(2,2,3,3,3-pentafluoro-propyl)-malonamide, or a pharmaceutically-acceptable salt thereof, and bevacizumab for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example a brain tumor.本発明は、増殖性疾患、特に固形腫瘍、例えば脳腫瘍に罹患した患者を治療するための、２,２-ジメチル-Ｎ-((Ｓ)-６-オキソ-６,７-ジヒドロ-５Ｈ-ジベンゾ[ｂ,ｄ]アゼピン-７-イル)-Ｎ'-(２,２,３,３,３-ペンタフルオロ-プロピル)-マロンアミド、又はその薬学的に許容可能な塩と、ベバシズマブとの併用療法に関する。
