Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.本發明揭示具有GPR17調控性質之磺醯胺化合物,其可用於治療或預防各種CNS及其他疾病,特別是用於預防及治療髓鞘形成疾病或病症。