LIPIDES DE CIBLAGE

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专利权人:

ALNYLAM PHARMACEUTICALS; INC.

发明人:

MANOHARAN, MUTHIAH,RAJEEV, KALLANTHOTTATHIL G.,NARAYANANNAIR, JAYAPRAKASH K.,JAYARAMAN, MUTHUSAMY

申请号：

CA2708173

公开号：

CA2708173C

申请日:

2008.12.04

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention provides targeting lipids of structure (Cl) L100 -linker - L101 where L100 is a lipid, lipophile,alkyl, alkenyl or alkynyl, L101 is a ligand or - CH2CH2(OCH2CH2)p O(CH2)q CH2-ligand, p is 1-1000, and q is 1-20. In addition, theinvention provides compositions and methods for the delivery of therapeuticagents to cells. In particular, these include novel lipidsand nucleic acid-lipid particles that provide efficient encapsulation ofnucleic acids and efficient delivery of the encapsulated nucleicaicd to cellsin vivo.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/