LIPIDES DE CIBLAGE

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专利权人:

Arbutus Biopharma Corporation

发明人:

申请号：

EP16001284.5

公开号：

EP3156077A1

申请日:

2008.12.04

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention provides targeting lipids of structure (Cl) L100 - linker - L101, where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or -CH2CH2(OCH2CH2)pO(CH2)qCH2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo.

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