BUR, Daniel,GRISOSTOMI, Corinna,NAYLER, Oliver,REMEN, Lubos,VERCAUTEREN, Magali,WELFORD, Richard
申请号：
ES14799475
公开号：
ES2650921T3
申请日:
2014.11.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula (I) ** Formula ** where X represents -CH2-, -CH2-CH2-, -CH2-CH2-CH2-, -S-, * -CH2-O-, or * -CH2-NRx - wherein Rx represents hydrogen, - CO- (C1-4) alkyl, - (C1-3) alkyl (C3-6) cycloalkyl, (C3-6) cycloalkyl, or -CO- (C1-4) alkoxy； in which the asterisks indicate the bond attached to the imidazole ring； R1a and R1b independently represent hydrogen, methyl, ethyl； or R1a and R1b together with the carbon atom to which they are attached to form a cyclopropyl ring； R2 represents aryl, or heteroaryl, wherein said aryl or heteroaryl is independently unsubstituted or mono-, di-, or, tri-substituted where the substituents are independently selected from: - C (1-4) alkyl； - (C1-4) alkoxy； - (C3-6) cycloalkyl； - (C1-3) fluoroalkyl； - (C1-3) fluoroalkoxy； - halogen； - cyano； - - (CH2) n-NR21R22； in which n represents the integer 0 or 1； and R21 and R22 independently represent hydrogen or (C1-4 alkyl)； or R21 and R22 together with the nitrogen atom to which they are attached to form a saturated ring of 4 to 7 members, wherein said ring optionally contains an oxygen atom of a ring； - -CO-NR23R24, wherein R23 and R24 independently represent hydrogen or C (1-4) alkyl； - -CO-NH-CN； - -NR25-CO-NR26R27, wherein R25, R26 and R27 independently represent hydrogen or C (1-4) alkyl； -CO- (C1-4) alkoxy； - phenyl； - hydroxy- (C1-4) alkyl； - (C1-3), C (1-4) alkoxy alkyl； - hydroxy- (C2-4) alkoxy； or - (C1-3), (C2-4) alkoxy； R3 represents aryl, or heteroaryl, wherein said aryl or heteroaryl is independently unsubstituted or mono-, di-, or, tri-substituted where the substituents are independently selected from: - -NR4-SO2- Y-R5, wherein R4 represents hydrogen or (C1-3) alkyl； And it represents a direct link； and R5 represents C (1-4) alkyl, or (C3-6) cycloalkyl； or R4 represents hydrogen or (C1-3) alkyl； Y represents -NRY - in which RY represents (C1-3 alkyl)； and R5 represents C (1-4) alkyl； or R4 and R5 together with the nitrogen and the -SO2-Y -group to which they are at
