Methods for treating cell proliferative disorders by administering virus toproliferative cells having an activated Ras-pathway are disclosed. The virusis administered so that it ultimately directly contacts proliferating cellshaving an activated Ras-pathway. Proliferative disorders include but are notlimited to neoplasms. The virus is selected from modified adenovirus, modifiedHSV, modified vaccinia virus and modified parapoxvirus orf virus. Alsodisclosed are methods for treating cell proliferative disorders by furtheradministering an immunosuppressive agent.
