N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or pharmaceutically acceptable salt thereof, and composition containing same as active ingredient for preventing or treating cancer
Kwangho Lee,Hyoung Rae Kim,Chi Hoon Park,Chong Ock Lee,Jong Kook Lee,Hee Jung Jung,Sung Yun Cho,Chong Hak Chae,Sang Un Choi,Jae Du Ha
申请号：
US14617079
公开号：
US09199944B2
申请日:
2015.02.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed herein are a new N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidin-2,4-diamine derivative or a pharmaceutically acceptable salt thereof and a pharmaceutical composition for the prevention or treatment of cancers containing the same as an active ingredient. The compound of the present invention has excellent inhibitory effects against the activities of anaplastic lymphoma kinase (ALK) and activated cdc42-associated kinase (ACK1) and thus can improve the therapeutic effects on the treatment of cancer cells having anaplastic lymphoma kinase fusion proteins such as EML4-ALK and NPM-ALK, and also effectively prevent the recurrence of cancers thus being useful as a pharmaceutical composition for the prevention and treatment of cancers.
