A composition with enhanced thermogenic activity and the use thereof in the prevention and treatment of obesityPharmaceutical compositions of a dietary supplement or medical device, useful for the treatment and prevention of overweight and obesity and metabolic syndrome comprising:a) menthol or a peppermint essential oil comprising menthol,in association with one or more components having a thermogenetic activity, selected from:b1) capsaicin or a capsacinoid derived from Capsicum genus or a Capsicum extract containing capsaicin and/or capsacinoidsb2) a sulphur containing active principle derived from the Allium genus or an Allium extract containing itb3) a catechin active substance derived from the genus Camellia or a Camellia extract containing it.The menthol and mint essential oil have a potentiating action on the biological activities of the other aforementioned components.