The present invention relates to peptides, nucleic acids and cells for use inimmunotherapeuticmethods. In particular, the present invention relates to the immunotherapy ofcancer. The presentinvention furthermore relates to tumor-associated cytotoxic T cell (CTL)peptide epitopes, aloneor in combination with other tumor-associated peptides that serve as activepharmaceuticalingredients of vaccine compositions that stimulate anti-tumor immuneresponses. The presentinvention relates to more than 70 novel peptide sequences and their variantsderived from HLAclass I and HLA class II molecules of human tumor cells that can be used invaccine compositionsfor eliciting anti-tumor immune responses.