SABBADINI ROGER A,WOJCIAK JONATHAN MICHAEL,HUXFORD TOM
申请号：
IN1382/MUMNP/2011
公开号：
IN2011MN01382A
申请日:
2011.07.04
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention provides crystalline forms of an anti-lipid antibody or fragment thereof, which may further comprise a lipid ligand of said antibody and/or salts, metals, or co-factors. Methods for making such crystals and co-crystals are provided. The lipid may be a bioactive lipid, including sphingolipids such as SIP. X-ray coordinates of such a crystal are provided, as are methods of using this information in antibody design or optimization. Methods for designing a humanized antibody to a lipid are provided. These methods may be performed in silico and may be intended to enhance binding affinity of an antibody to its original target lipid, and/or to alter binding specificity. Antibodies produced by these methods are also provided.
