CORKEY, BRITTON KENNETH,ELZEIN, ELFATIH,JIANG, ROBERT H.,KALLA, RAO V.,KOLTUN, DMITRY,LI, XIAOFENG,MARTINEZ, RUBEN,PARKHILL, ERIC Q.,PERRY, THAO,ZABLOCKI, JEFF,VENKATARAMANI, CHANDRASEKAR,GRAUPE, MICH
申请号：
PE0028172013
公开号：
PE06902014A1
申请日:
2012.06.29
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to compounds of formula (IA) benzoxazepinonas merged with Cy is cycloalkyl, aryl, heteroaryl, among others Q is a Covalent Bond, or alquileno (C0) 2, alquinileno (C2), among others M is 0 to 3 n is 0 to 5 R10 its Halo, NO2, CN, (CH3) 3, among others R2 is - Lquileno (C1 - C6) - R5, - L - L - alquileno R5, (C1 - C6 - R5), among others, where l is o, S, C (or NHS), (OR) 2R5 is among others, cycloalkyl, aryl, heteroaryl, among others R3 is H, alkyl, aryl (C1 - C6), among others R4 is H, cycloalkyl, aryl, among others.Preferred compounds are: 4 - ((3 - metiloxetan - 3 - yl) methyl) - 7 - (4 - (trifluoromethoxy) phenyl) - 3,4 - dihidrobenzo [f] [1,4] oxazepin - 3 (2H) - One 4 - (2 - (pyrrolidin-1-yl) ethyl) - 7 - (4 - (trifluoromethoxy) phenyl) - 3,4 - dihidrobenzo [f] [1,4] oxazepin - 3 (2H) - One 4 - (5 - cyclobutyl - 1,3,4-oxadiazol-2 - yl) methyl) - 7 - (4 - (trifluoromethoxy) f Enil) - 3,4 - dihidrobenzo [f] [1,4] oxazepin - 3 (2H) - One among others.It also relates to a Pharmaceutical composition. These compounds are sodium channel blockers late being useful in the treatment of arrhythmia, Heart Failure, myocardial infarction, diabetesSE REFIERE A COMPUESTOS DERIVADOS DE BENZOXAZEPINONAS FUSIONADAS DE FORMULA (IA) DONDE Cy ES ARILO, CICLOALQUILO, HETEROARILO, ENTRE OTROS Q ES UN ENLACE COVALENTE, -O-ALQUILENO(C0-2), ALQUINILENO(C2), ENTRE OTROS m ES DE 0 A 3 n ES DE 0 A 5 R10 ES HALO, NO2, CN, Si(CH3)3, ENTRE OTROS R2 ES -ALQUILENO(C1-C6)-R5, -L-R5, -L-ALQUILENO(C1-C6)-R5, ENTRE OTROS, EN DONDE L ES O, S, C(O), NHS(O)2, ENTRE OTROS R5 ES CICLOALQUILO, ARILO, HETEROARILO, ENTRE OTROS R3 ES H, ALQUILO(C1-C6), ARILO, ENTRE OTROS R4 ES H, CICLOALQUILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-((3-METILOXETAN-3-IL)METIL)-7-(4-(TRIFLUOROMETOXI)FENIL)-3,4-DIHIDROBENZO[f][1,4]OXAZEPIN-5(2H)-ONA 4-(2-(PIRROLIDIN-1-IL)ETIL)-7-(4-(TRIFLUOROMETOXI)FENIL)-3,4-DIHIDROBENZO[f][1,4]OXAZEPIN-5(2H)-ONA 4-((5-CICLOBUTIL-1,3,4-OXADIAZOL-2-IL)METIL)-7-(4-(TRIFLUOROMETOXI
