BRUCE, Ian,CHAMOIN, Sylvie,COLLINGWOOD, Stephen Paul,FURET, Pascal,FURMINGER, Vikki,LEWIS, Sarah,LOREN, Jon Christopher,MOLTENI, Valentina,SAUNDERS, Alex Michael,SHAW, Duncan,SVIRIDENKO, Lilya,THOMSON
申请号：
ES12772493
公开号：
ES2585048T3
申请日:
2012.08.31
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound represented by the formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, wherein, A is ** Formula ** R1 is C1-C4 alkyl； C1-C4 alkoxy optionally substituted by one or more halogen atoms； CN； or halogen； R1a is H, halogen, C1-C4 alkyl or C1-C4 haloalkyl； X is N or CH； R2 is H； C1-C8 alkyl optionally substituted by one or more OH, -NR9R11 or C1-C4 alkoxy； C1-C8 haloalkyl； C2-C8 alkynyl substituted by one or more halogen, OH, - NR9R11 or C1-C4 alkoxy； C3-C10 cycloalkyl； - (C1-C4 alkyl) -C3-C8 cycloalkyl； C1-C8 alkoxy optionally substituted by one or more halogen, -NR9R11 or OH； OH； CN； halogen； - (C0-C4 alkyl) -NR9R11； - (C0-C4 alkyl) -CO2R15； - (C0-C4 alkyl) -C (O) NR9R11； - (C0-C4 alkyl) -C6-C14 aryl； or - (C0-C4 alkyl) - 3- to 14-membered heterocyclyl； wherein the cycloalkyl, - (C0-C4 alkyl) -C6-C14 alkyl and - (C0-C4 alkyl) -heterocyclyl of 3 to 14 members are each optionally substituted by one or more Za substituents； R3 is H； C1-C8 alkyl optionally substituted by one or more OH, -NR9R11 or C1-C4 alkoxy； C1-C8 haloalkyl； C2-C8 alkynyl substituted by one or more halogen, OH, - NR9R11, or C1-C4 alkoxy； C3-C10 cycloalkyl； - (C1-C4 alkyl) -C3-C8 cycloalkyl； C1-C8 alkoxy optionally substituted by one or more halogen, -NR9R11 or OH； OH； CN； halogen； - (C0-C4 alkyl) -NR9R11； - (C0-C4 alkyl) -CO2R15； - (C0-C4 alkyl) -C (O) NR9R11； - (C0-C4 alkyl) -C6-C14 aryl； or - (C0-C4 alkyl) - 3- to 14-membered heterocyclyl； wherein the cycloalkyl, - (C0-C4 alkyl) -C6-C14 alkyl and - (C0-C4 alkyl) -heterocyclyl of 3 to 14 members are each optionally substituted by one or more Za substituents； each Za is independently OH； (C0-C4 alkyl) -C6 aryl； C6 O-aryl； C1-C4 alkyl optionally substituted by one or more OH, CN or -NR19aR21a； C1-C4 haloalkyl； C1-C4 alkoxy optionally substituted by one or more OH, -CO2R19a, - NR19aR21a or C1-C4 alkoxy； -NR18aC (O) R21a； -C (O) NR19aR21a； -NR18aC (O) NR19aR21a； -NR19aR21a； - (C0-C4 alkyl) -C (O) OR18a； - (C0-C4 alkyl) -C (O)
